eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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SCImago Journal & Country Rank
4/2023
vol. 20
 
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abstract:
Original paper

A systematic review and meta-analysis to evaluate blood levels of interleukin-6 in lung cancer patients

Seyed Vahid Jasemi
1
,
Soha Zia
2
,
Seyed Ghasem Mirbahari
3
,
Masoud Sadeghi
4

  1. Department of Internal Medicine, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. Jam Private Medical Laboratory, Kermanshah, Iran
  4. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Kardiochirugia i Torakochirurgia Polska 2023; 20 (4): 240-250
Online publish date: 2024/01/11
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Introduction
The exact mechanism responsible for inflammation in malignancy is not completely understood, but it is possible that interleukin-6 (IL-6) plays a major role in triggering and maintaining an inflammatory response.

Aim
To conduct a systematic review and meta-analysis of the levels of IL-6 in the serum/plasma of lung cancer (LC) patients.

Material and methods
The researchers searched four databases up to September 11, 2022, to find studies that reported on IL-6 levels in LC patients compared to healthy controls (HCs). They calculated effect sizes using standardized mean difference (SMD) with a 95% confidence interval (CI). To evaluate the quality of each study, they used the Newcastle-Ottawa Scale (NOS). They performed subgroup analysis, sensitivity analysis, meta-regression analysis, heterogeneity analyses, trial sequential analysis, and publication bias with the trim-and-fill method.

Results
The meta-analysis included 28 studies, and the results showed that the pooled SMD was 1.71 (95% CI: 1.22, 2.19; p < 0.00001; I2 = 98%), indicating that LC patients had significantly higher levels of IL-6 in their serum/plasma than HCs.

Conclusions
The study found that the publication year and quality score of the studies were positively associated with the level of IL-6, while the sample size was inversely related. The research suggests that measuring IL-6 levels in the blood could be useful for detecting and monitoring LC as it appears to be a reliable biomarker.

keywords:

lung neoplasm, serum, plasma, interleukin-6, meta-analysis

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